Clemson Tigers vs Duke Blue Devils: Betting Line, Odds & Head-to-Head Breakdown

NCAAF · 2026 Season · Odds via DraftKings

As of now, this game hasn't started yet. It's scheduled for 11/20 - 7:30 PM EST at Wallace Wade Stadium. Check back once the game is underway for live score updates.

Heading into this NCAAF matchup, DraftKings lists the Duke Blue Devils as the favorite at DUKE -8.5, with the Clemson Tigers sitting as the underdog on the moneyline. The point spread currently sits at -8.5, and the over/under total for the game is set at 44.5, giving an early read on how competitive, and how high-scoring, oddsmakers expect this game to be.

Season-series history between the Clemson Tigers and Duke Blue Devils isn't available for this matchup yet, so there's no head-to-head trend to lean on heading into game day.

Interestingly, the betting market and ESPN's statistical Matchup Predictor are in agreement here, both point to the Duke Blue Devils as the side more likely to come out on top, with the model putting their win probability at 79%. When the numbers and the odds line up this closely, it's usually a sign the gap between these two teams is real, not just a betting-market quirk.

Season-long standings context for both sides isn't meaningful yet at this point in the schedule, but the early betting line already gives a decent snapshot of how oddsmakers expect this NCAAF matchup to unfold.

Betting lines, like win probabilities, are a snapshot, not a forecast set in stone, and they can shift right up until the 11/20 - 7:30 PM EST start time as injury news, weather, and public money move the market. This page will keep reflecting the latest numbers as they update, so it's worth a final check before Clemson Tigers and Duke Blue Devils actually take the field.

Odds are for informational purposes only and are subject to change. Please gamble responsibly.