Syracuse Orange vs Louisville Cardinals
LOU
4-3
SYR
2-4 Frequently Asked Questions
What channel is the Louisville Cardinals vs Syracuse Orange game on?
What time does the NCAAF game start?
Where is the game being played?
Who is favored to win, Louisville Cardinals or Syracuse Orange?
Is this page safe to use, and does it track my personal data?
Louisville Cardinals vs Syracuse Orange: Betting Line, Odds & Head-to-Head Breakdown
NCAAF · 2026 Season · Odds via Draft Kings
This game has ended. The Louisville Cardinals defeated the Syracuse Orange, 34-26. You can find the full box score and recap above.
Heading into this NCAAF matchup, Draft Kings lists the Louisville Cardinals as the favorite at LOU -14.5, with the Syracuse Orange sitting as the underdog on the moneyline. The point spread currently sits at 14.5, and the over/under total for the game is set at 56.5, giving an early read on how competitive, and how high-scoring, oddsmakers expect this game to be.
Season-series history between the Louisville Cardinals and Syracuse Orange isn't available for this matchup yet, so there's no head-to-head trend to lean on heading into game day.
Season-long standings context for both sides isn't meaningful yet at this point in the schedule, but the early betting line already gives a decent snapshot of how oddsmakers expect this NCAAF matchup to unfold.
Betting lines, like win probabilities, are a snapshot, not a forecast set in stone, and they can shift right up until the Final start time as injury news, weather, and public money move the market. This page will keep reflecting the latest numbers as they update, so it's worth a final check before Louisville Cardinals and Syracuse Orange actually take the field.
Odds are for informational purposes only and are subject to change. Please gamble responsibly.