DEN
2-2
SF
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Denver Broncos vs San Francisco 49ers: Betting Line, Odds & Head-to-Head Breakdown
NFL · 2026 Season · Odds via Draft Kings
This game has ended. The San Francisco 49ers defeated the Denver Broncos, 24-14. You can find the full box score and recap above.
Heading into this NFL matchup, Draft Kings lists the San Francisco 49ers as the favorite at SF -3, with the Denver Broncos sitting as the underdog on the moneyline. The point spread currently sits at -3, and the over/under total for the game is set at 48.5, giving an early read on how competitive, and how high-scoring, oddsmakers expect this game to be.
Season-series history between the Denver Broncos and San Francisco 49ers isn't available for this matchup yet, so there's no head-to-head trend to lean on heading into game day.
That betting line lines up with what the standings show. The Denver Broncos currently carry a .500 win percentage on the season, compared to 1.000 for the San Francisco 49ers. Whether that gap on paper translates to the scoreboard is a different question entirely, standings measure a whole season, while a single game can turn on one swing, one drive, or one bad quarter.
Betting lines, like win probabilities, are a snapshot, not a forecast set in stone, and they can shift right up until the Final start time as injury news, weather, and public money move the market. This page will keep reflecting the latest numbers as they update, so it's worth a final check before Denver Broncos and San Francisco 49ers actually take the field.
Odds are for informational purposes only and are subject to change. Please gamble responsibly.