Arizona Cardinals vs Detroit Lions
DET
3-2 
ARI
1-4 Team Leaders
Arizona Cardinals
J. Brissett
J. Love
K. Bourne
B. Baker
B. Baker
Detroit Lions
J. Goff
J. Gibbs
S. LaPorta
D. Wonnum
J. Campbell
Division Standings
2026 NFC North Standings
| Team | W | L | T | PCT | PF | PA | Any |
|---|---|---|---|---|---|---|---|
Minnesota
|
5 | 0 | 0 | 1.000 | 109 | 64 | 5-0 |
Green Bay
|
3 | 2 | 0 | .600 | 104 | 112 | 3-2 |
Chicago
|
3 | 2 | 0 | .600 | 119 | 96 | 3-2 |
|
Detroit
|
3 | 2 | 0 | .600 | 164 | 148 | 3-2 |
2026 NFC West Standings
| Team | W | L | T | PCT | PF | PA | Any |
|---|---|---|---|---|---|---|---|
San Francisco
|
4 | 0 | 0 | 1.000 | 122 | 64 | 4-0 |
Seattle
|
3 | 1 | 0 | .750 | 105 | 73 | 3-1 |
Los Angeles
|
2 | 2 | 0 | .500 | 85 | 83 | 2-2 |
|
Arizona
|
1 | 4 | 0 | .200 | 108 | 162 | 1-4 |
Injured Players
Arizona Cardinals
| Player | Status | Est. Return |
|---|---|---|
|
Questionable | 2026-10-11 |
|
Out | 2026-10-18 |
|
Out | 2026-10-18 |
|
Out | 2026-10-18 |
|
Out | 2026-10-18 |
Detroit Lions
| Player | Status | Est. Return |
|---|---|---|
|
Questionable | 2026-10-25 |
|
Questionable | 2026-10-25 |
|
Out | 2026-10-25 |
|
Out | 2026-10-25 |
|
Out | 2026-10-25 |
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Detroit Lions vs Arizona Cardinals: Betting Line, Odds & Head-to-Head Breakdown
NFL · 2026 Season · Odds via DraftKings
This game has ended. The Detroit Lions defeated the Arizona Cardinals, 45-21. You can find the full box score and recap above.
Heading into this NFL matchup, DraftKings lists the Detroit Lions as the favorite at DET -4.5, with the Arizona Cardinals sitting as the underdog on the moneyline. The point spread currently sits at 4.5, and the over/under total for the game is set at 55.5, giving an early read on how competitive, and how high-scoring, oddsmakers expect this game to be.
Season-series history between the Detroit Lions and Arizona Cardinals isn't available for this matchup yet, so there's no head-to-head trend to lean on heading into game day.
That betting line lines up with what the standings show. The Detroit Lions currently carry a .600 win percentage on the season, compared to .200 for the Arizona Cardinals. Whether that gap on paper translates to the scoreboard is a different question entirely, standings measure a whole season, while a single game can turn on one swing, one drive, or one bad quarter.
Betting lines, like win probabilities, are a snapshot, not a forecast set in stone, and they can shift right up until the Final start time as injury news, weather, and public money move the market. This page will keep reflecting the latest numbers as they update, so it's worth a final check before Detroit Lions and Arizona Cardinals actually take the field.
Odds are for informational purposes only and are subject to change. Please gamble responsibly.