IND
2-4 
JAX
4-2 Team Leaders
Jacksonville Jaguars
T. Lawrence
B. Tuten
P. Washington
T. Walker
F. Oluokun
Indianapolis Colts
D. Jones
J. Taylor
J. Downs
D. Buckner
A. Davis-Gaither
Recent Form
Jacksonville Jaguars
Indianapolis Colts
Division Standings
2026 AFC South Standings
| Team | W | L | T | PCT | PF | PA | Any |
|---|---|---|---|---|---|---|---|
|
Jacksonville
|
4 | 2 | 0 | .667 | 154 | 104 | 4-2 |
|
Indianapolis
|
2 | 4 | 0 | .333 | 144 | 164 | 2-4 |
Houston
|
2 | 4 | 0 | .333 | 144 | 143 | 2-4 |
Tennessee
|
1 | 5 | 0 | .167 | 84 | 129 | 1-5 |
Injured Players
Jacksonville Jaguars
| Player | Status | Est. Return |
|---|---|---|
|
Questionable | 2026-11-01 |
|
Questionable | 2026-11-01 |
|
Questionable | 2026-11-01 |
|
Injured Reserve | 2026-11-22 |
|
Injured Reserve | 2026-11-15 |
Indianapolis Colts
| Player | Status | Est. Return |
|---|---|---|
|
Questionable | 2026-10-25 |
|
Questionable | 2026-10-25 |
|
Questionable | 2026-10-25 |
|
Questionable | 2026-10-25 |
|
Questionable | 2026-10-25 |
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Indianapolis Colts vs Jacksonville Jaguars: Betting Line, Odds & Head-to-Head Breakdown
NFL · 2026 Season · Odds via DraftKings
As of now, this game hasn't started yet. It's scheduled for 11/1 - 1:00 PM EST at EverBank Stadium. Check back once the game is underway for live score updates.
Heading into this NFL matchup, DraftKings lists the Jacksonville Jaguars as the favorite at JAX -7.5, with the Indianapolis Colts sitting as the underdog on the moneyline. The point spread currently sits at -7.5, and the over/under total for the game is set at 47.5, giving an early read on how competitive, and how high-scoring, oddsmakers expect this game to be.
Season-series history between the Indianapolis Colts and Jacksonville Jaguars isn't available for this matchup yet, so there's no head-to-head trend to lean on heading into game day.
Interestingly, the betting market and ESPN's statistical Matchup Predictor are in agreement here, both point to the Jacksonville Jaguars as the side more likely to come out on top, with the model putting their win probability at 75%. When the numbers and the odds line up this closely, it's usually a sign the gap between these two teams is real, not just a betting-market quirk.
That betting line lines up with what the standings show. The Indianapolis Colts currently carry a .333 win percentage on the season, compared to .667 for the Jacksonville Jaguars. Whether that gap on paper translates to the scoreboard is a different question entirely, standings measure a whole season, while a single game can turn on one swing, one drive, or one bad quarter.
Betting lines, like win probabilities, are a snapshot, not a forecast set in stone, and they can shift right up until the 11/1 - 1:00 PM EST start time as injury news, weather, and public money move the market. This page will keep reflecting the latest numbers as they update, so it's worth a final check before Indianapolis Colts and Jacksonville Jaguars actually take the field.
Odds are for informational purposes only and are subject to change. Please gamble responsibly.