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2-6 Frequently Asked Questions
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Miami Dolphins vs Indianapolis Colts: Betting Line, Odds & Head-to-Head Breakdown
NFL · 2026 Season · Odds via DraftKings
As of now, this game hasn't started yet. It's scheduled for 11/15 - 1:00 PM EST at Lucas Oil Stadium. Check back once the game is underway for live score updates.
Heading into this NFL matchup, DraftKings lists the Indianapolis Colts as the favorite at IND -2.5, with the Miami Dolphins sitting as the underdog on the moneyline. The point spread currently sits at -2.5, and the over/under total for the game is set at 43.5, giving an early read on how competitive, and how high-scoring, oddsmakers expect this game to be.
Season-series history between the Miami Dolphins and Indianapolis Colts isn't available for this matchup yet, so there's no head-to-head trend to lean on heading into game day.
Interestingly, the betting market and ESPN's statistical Matchup Predictor are in agreement here, both point to the Indianapolis Colts as the side more likely to come out on top, with the model putting their win probability at 71%. When the numbers and the odds line up this closely, it's usually a sign the gap between these two teams is real, not just a betting-market quirk.
That betting line lines up with what the standings show. The Miami Dolphins currently carry a .143 win percentage on the season, compared to .250 for the Indianapolis Colts. Whether that gap on paper translates to the scoreboard is a different question entirely, standings measure a whole season, while a single game can turn on one swing, one drive, or one bad quarter.
Betting lines, like win probabilities, are a snapshot, not a forecast set in stone, and they can shift right up until the 11/15 - 1:00 PM EST start time as injury news, weather, and public money move the market. This page will keep reflecting the latest numbers as they update, so it's worth a final check before Miami Dolphins and Indianapolis Colts actually take the field.
Odds are for informational purposes only and are subject to change. Please gamble responsibly.